Epstein-Barr Virus-Associated Inflammatory Pseudotumor-Like Follicular Dendritic Cell Tumor of the Spleen without Recurrence for 3 Years after Splenectomy

Inflammatory pseudotumor (IPT)-like follicular dendritic cell (FDC) tumor is a rare disease with distinct clinicopathological features. We report a case of so-called Epstein-Barr virus (EBV)- associated IPT-like FDC tumor of the spleen. We found a splenic mass lesion during his annual checkup. After recognizing the growing mass, splenectomy was performed. Histopathological and immunohistological studies revealed extensive proliferation of spindle cells positive for FDC markers. EBV was exclusively detected on these spindle cells by in situ hybridization analysis. Based on these findings, a diagnosis of EBV-associated IPT-like FDC tumor was made. Of note, neither recurrence nor metastasis occurred within 3 years postsplenectomy.