Uterine fibroid is a common gynecological benign tumor but can markedly deteriorate women’s quality of life. Women with uterine fibroids may suffer from abdominal discomfort, pressure symptoms, menorrhagia, and severe anemia. Women athletes suffering from uterine fibroids are often not permitted to take any hormone or NSAID drugs to control their symptoms. This may interfere with the checking of urine samples after an international competition. This may disturb their tight training schedule and affect their sports performance if these happen. Sometimes, even though surgery can remove the fibroids, these young athletes do not welcome surgery as post-operative rest can be up to 6 weeks after (traditional) surgery. The efficacy and safety of focused ultrasound surgery (FUS) therapy for treating uterine fibroids has been increasingly recognized. This paper reports HIFU ablation treatment for a woman athlete with a uterine fibroid suffering from anemia, fibroid recurrence, and pressure symptoms. After HIFU treatment, she resumes her normal exercise and sports with a satisfactory result. This may be the first case report of the use of HIFU ablation in athletes to the best of our knowledge, thus highlighting the unique advantages of HIFU treatment for athletes.